Multifactor dimensionality reduction (MDR) is a statistical approach, also used in machine learning automatic approaches, for detecting and characterizing combinations of attributes or independent variables that interact to influence a dependent or class variable. MDR was designed specifically to identify nonadditive interactions among discrete variables that influence a binary outcome and is considered a nonparametric and model-free alternative to traditional statistical methods such as logistic regression. The basis of the MDR method is a constructive induction or feature engineering algorithm that converts two or more variables or attributes to a single attribute. This process of constructing a new attribute changes the representation space of the data. The end goal is to create or discover a representation that facilitates the detection of nonlinear or nonadditive interactions among the attributes such that prediction of the class variable is improved over that of the original representation of the data. == Illustrative example == Consider the following simple example using the exclusive OR (XOR) function. XOR is a logical operator that is commonly used in data mining and machine learning as an example of a function that is not linearly separable. The table below represents a simple dataset where the relationship between the attributes (X1 and X2) and the class variable (Y) is defined by the XOR function such that Y = X1 XOR X2. Table 1 A machine learning algorithm would need to discover or approximate the XOR function in order to accurately predict Y using information about X1 and X2. An alternative strategy would be to first change the representation of the data using constructive induction to facilitate predictive modeling. The MDR algorithm would change the representation of the data (X1 and X2) in the following manner. MDR starts by selecting two attributes. In this simple example, X1 and X2 are selected. Each combination of values for X1 and X2 are examined and the number of times Y=1 and/or Y=0 is counted. In this simple example, Y=1 occurs zero times and Y=0 occurs once for the combination of X1=0 and X2=0. With MDR, the ratio of these counts is computed and compared to a fixed threshold. Here, the ratio of counts is 0/1 which is less than our fixed threshold of 1. Since 0/1 < 1 we encode a new attribute (Z) as a 0. When the ratio is greater than one we encode Z as a 1. This process is repeated for all unique combinations of values for X1 and X2. Table 2 illustrates our new transformation of the data. Table 2 The machine learning algorithm now has much less work to do to find a good predictive function. In fact, in this very simple example, the function Y = Z has a classification accuracy of 1. A nice feature of constructive induction methods such as MDR is the ability to use any data mining or machine learning method to analyze the new representation of the data. Decision trees, neural networks, or a naive Bayes classifier could be used in combination with measures of model quality such as balanced accuracy and mutual information. == Machine learning with MDR == As illustrated above, the basic constructive induction algorithm in MDR is very simple. However, its implementation for mining patterns from real data can be computationally complex. As with any machine learning algorithm there is always concern about overfitting. That is, machine learning algorithms are good at finding patterns in completely random data. It is often difficult to determine whether a reported pattern is an important signal or just chance. One approach is to estimate the generalizability of a model to independent datasets using methods such as cross-validation. Models that describe random data typically don't generalize. Another approach is to generate many random permutations of the data to see what the data mining algorithm finds when given the chance to overfit. Permutation testing makes it possible to generate an empirical p-value for the result. Replication in independent data may also provide evidence for an MDR model but can be sensitive to difference in the data sets. These approaches have all been shown to be useful for choosing and evaluating MDR models. An important step in a machine learning exercise is interpretation. Several approaches have been used with MDR including entropy analysis and pathway analysis. Tips and approaches for using MDR to model gene-gene interactions have been reviewed. == Extensions to MDR == Numerous extensions to MDR have been introduced. These include family-based methods, fuzzy methods, covariate adjustment, odds ratios, risk scores, survival methods, robust methods, methods for quantitative traits, and many others. == Applications of MDR == MDR has mostly been applied to detecting gene-gene interactions or epistasis in genetic studies of common human diseases such as atrial fibrillation, autism, bladder cancer, breast cancer, cardiovascular disease, hypertension, obesity, pancreatic cancer, prostate cancer and tuberculosis. It has also been applied to other biomedical problems such as the genetic analysis of pharmacology outcomes. A central challenge is the scaling of MDR to big data such as that from genome-wide association studies (GWAS). Several approaches have been used. One approach is to filter the features prior to MDR analysis. This can be done using biological knowledge through tools such as BioFilter. It can also be done using computational tools such as ReliefF. Another approach is to use stochastic search algorithms such as genetic programming to explore the search space of feature combinations. Yet another approach is a brute-force search using high-performance computing. == Implementations == www.epistasis.org provides an open-source and freely-available MDR software package. An R package for MDR. An sklearn-compatible Python implementation. An R package for Model-Based MDR. MDR in Weka. Generalized MDR.
GoodRx
GoodRx Holdings, Inc. is an American healthcare company that operates a telemedicine platform and free-to-use website and mobile app that track prescription drug prices in the United States and provide drug coupons for discounts on medications. GoodRx compares prescription drug prices at more than 75,000 pharmacies in the United States. The platform allows users to consult a doctor online and obtain a prescription for certain types of medications. == History == === Financial performance === GoodRx was founded in Santa Monica, California in 2011. GoodRx experienced substantial growth in net income in 2017 ($9 million), 2018 ($44 million), and 2019 ($66 million), but recorded a loss of $293.6 million in 2020 due to IPO-related expenses. In September 2020, GoodRx went public on the Nasdaq under the ticker symbol GDRX. The company priced its initial public offering at $33 per share, above the expected range of $24 to $28, raising more than $1.1 billion at an initial valuation of approximately $12.7 billion. In the first half of 2020, the company reported revenues of $257 million and net income of $55 million. GoodRx generated $745.4 million in revenue for the full year 2021, a 35.36% increase over 2020. During the first half of 2021, the company’s share price declined by 10.7%. The decline was attributed to increased competition in online pharmacy services and slower user growth. GoodRx reported full-year revenue of $766.6 million, with adjusted EBITDA reaching $213.5 million, exceeding guidance in the fourth quarter. GoodRx reported that 41% of prescriptions filled using its coupons were newly adherent, meaning they would not have been filled without the service. GoodRx reported a full-year 2023 revenue of $750.3 million, a decrease of 2.1% from 2022. However, its fourth-quarter revenue increased by 7% year-over-year. GoodRx achieved an Adjusted EBITDA of $217.4 million for the year and an Adjusted EBITDA Margin of 28.6%. In 2024, GoodRx achieved 6% revenue growth with $792.3 million for the full year and turned a net loss into a positive net income of $16.4 million. The company also demonstrated strong operational efficiency, with a 32.8% increase in full-year Adjusted EBITDA. In Q2 2025, GoodRx reported revenue of $203.1 million, a 1.2% increase from the previous year, and a net income of $12.8 million, a significant 92% jump, which resulted in a 6.3% net income margin. However, prescription transaction revenue declined by 3% due to a decrease in monthly active consumers, but this was offset by strong 32% growth in its Pharma Manufacturer Solutions business. GoodRx also saw a 7% decrease in subscription revenue. === Mergers and acquisitions === In 2019, GoodRx acquired HeyDoctor, a telemedicine company, to integrate virtual healthcare services into the platform. In 2021, a health video content producer, HealthiNation was acquired by GoodRx, which helped provide consumers with health information and offered pharmaceutical manufacturers new ways to reach relevant audiences. In April 2022, GoodRx acquired VitaCare Prescription Services from TherapeuticsMD to strengthen its pharma manufacturer solutions business. === Partnerships === In 2017, the company announced partnerships with major pharmaceutical companies to negotiate lower prescription drug costs. GoodRx has deep relationships with major pharmacy chains, including Walgreens, Walmart, CVS Caremark, and Publix, to allow customers to use GoodRx discounts and Gold benefits. GoodRx began its partnership with CVS Caremark in July 2023 to automatically apply coupons to insured CVS customers purchasing generic prescriptions at certain locations. In April 2024, GoodRx added Publix into its network, allowing GoodRx Gold members to use their cards at Publix Pharmacies. GoodRx partners with Pharmacy Benefit Management like Caremark, Express Scripts, and MedImpact to apply their savings directly to eligible insurance plans and members. GoodRx partners with companies like Affirm, Benefitfocus, and DoorDash to integrate their services that offer members discounts and financial flexibility for prescriptions. GoodRx also partners with organizations like the American Academy of Family Physicians Foundation to support broader access to care. In October 2022, GoodRx launched Provider Mode, which allows healthcare providers to use the app to compare costs of drugs for patients based on different payment methods and drug alternatives. In 2025, GoodRx partnered with Novo Nordisk to offer discounted cash-pay access to semaglutide products like Ozempic and Wegovy through its platform and participating pharmacies. == Products and services == GoodRx started its telemedicine service GoodRx Care in September 2019. It lets people talk to a licensed provider online for common issues and get prescriptions even if they don't have insurance. They also run condition-specific subscription plans that bundle online doctor visits, FDA-approved meds, and home delivery into one monthly payment. On the weight management side, GoodRx offers prescriptions for GLP-1 drugs like semaglutide through their telemedicine platform. This got a boost when the oral version of Wegovy became widely available in the US in early 2026. GoodRx works with drug makers like Novo Nordisk to make some medications (including semaglutide options) more affordable for people paying cash. The telemedicine part took off after GoodRx bought HeyDoctor in 2019 and brought their virtual care tools into the main platform. == Key people == The Santa Monica-based startup was founded in September 2011 by Trevor Bezdek and former Facebook executives Doug Hirsch and Scott Marlette. Marlette was one of the first 20 employees at Facebook and built Facebook's photo application. In 2005, Hirsch was the Vice President of Product at Facebook, working closely with Mark Zuckerberg. Bezdek and Hirsch served as co-chief executive officers until April 2023, when they stepped down from those roles and technology executive Scott Wagner was appointed interim chief executive officer. Bezdek became chair of the board, while Hirsch took on the role of chief mission officer. In December 2024, GoodRx announced that healthcare executive Wendy Barnes would become president and chief executive officer effective January 1, 2025. As of 2025, Barnes serves as the company’s CEO, while Trevor Bezdek and Scott Wagner serve as co-chairs of the board, and Doug Hirsch remains involved as a co-founder and senior executive. == Controversy == On February 25, 2020, Consumer Reports published an article stating that GoodRx shared user data—specifically, pseudonymized advertising ID numbers that companies use to track the behavior of web users across websites, the names of the drugs that users browsed, and the pharmacies where users sought to fill prescriptions—with Google, Facebook, and around twenty other Internet-based companies. A few days later, GoodRx released a statement saying that it had made changes to prevent user search data on medical conditions and pharmaceuticals from being shared with Facebook. In March 2020, GoodRx stopped sending data about user prescriptions to Facebook. On February 1, 2023, the Federal Trade Commission fined GoodRx US$1.5 million for violations of the Breach Notification Rule and the Federal Trade Commission Act for allegedly failing to obtain specific, informed, and unambiguous consent from users before disclosing health-related information to Facebook and Google. In November 2024, independent pharmacies filed at least three class action lawsuits against GoodRx and major pharmacy benefit managers. The cases, brought by independent pharmacies in California, Michigan, Pennsylvania, and Rhode Island, allege that GoodRx and the PBMs collaborated to suppress reimbursements for generic prescription drugs. They allege that agreements using GoodRx’s software suppressed reimbursements for generic drugs and violated the Sherman Antitrust Act. The suits claim the practices amount to price fixing which harms small pharmacies while benefiting PBMs and their affiliates. GoodRx settled both the 2023 FTC action and the 2025 class action lawsuit without admitting wrongdoing.
Edward Stabler
Edward Stabler is a Professor of Linguistics at the University of California, Los Angeles. His primary areas of research are (1) Natural Language Processing (NLP), (2) Parsing and formal language theory, and (3) Philosophy of Logic and Language. He was a member of the faculty at UCLA from 1984 to 2016. His work involves the production of software for minimalist grammars (MGs) and related systems. == Early life and education == Stabler received his Ph.D. from the Department of Linguistics and Philosophy at MIT in 1981. == Recent publications == Edward Stabler (2011) Computational perspectives on minimalism. Revised version in C. Boeckx, ed, Oxford Handbook of Linguistic Minimalism, pp. 617–642. Edward Stabler (2010) A defense of this perspective against the Evans&Levinson critique appears here, with revised version in Lingua 120(12): 2680-2685. Edward Stabler (2010) After GB. Revised version in J. van Benthem & A. ter Meulen, eds, Handbook of Logic and Language, pp. 395–414. Edward Stabler (2010) Recursion in grammar and performance. Presented at the 2009 UMass recursion conference. Edward Stabler (2009) Computational models of language universals. Revised version appears in M. H. Christiansen, C. Collins, and S. Edelman, eds., Language Universals, Oxford: Oxford University Press, pages 200-223. Edward Stabler (2008) Tupled pregroup grammars. Revised version appears in P. Casadio and J. Lambek, eds., Computational Algebraic Approaches to Natural Language, Milan: Polimetrica, pages 23–52. Edward Stabler (2006) Sidewards without copying. Proceedings of the 11th Conference on Formal Grammar, edited by P. Monachesi, G. Penn, G. Satta, and S. Wintner. Stanford: CSLI Publications, 2006, pages 133-146.
Top 10 AI Headshot Generators Compared (2026)
Trying to pick the best AI headshot generator? An AI headshot generator is software that uses machine learning to help you get more done — it scales effortlessly from a single task to thousands. The best picks balance beginner-friendly simplicity with the depth power users need, and they ship updates often. Whether you are a beginner or a pro, the right AI headshot generator slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.
The Best Free AI Text-to-image Tool for Beginners
Looking for the best AI text-to-image tool? An AI text-to-image tool is software that uses machine learning to help you get more done — it can save you hours every week by automating repetitive work. Most options offer a generous free tier, with paid plans unlocking higher limits, faster processing, and team features. Whether you are a beginner or a pro, the right AI text-to-image tool slots into your workflow and pays for itself fast. This guide breaks down the top picks, their pros and cons, and who each one is best for.
Visual temporal attention
Visual temporal attention is a special case of visual attention that involves directing attention to specific instant of time. Similar to its spatial counterpart visual spatial attention, these attention modules have been widely implemented in video analytics in computer vision to provide enhanced performance and human interpretable explanation of deep learning models. As visual spatial attention mechanism allows human and/or computer vision systems to focus more on semantically more substantial regions in space, visual temporal attention modules enable machine learning algorithms to emphasize more on critical video frames in video analytics tasks, such as human action recognition. In convolutional neural network-based systems, the prioritization introduced by the attention mechanism is regularly implemented as a linear weighting layer with parameters determined by labeled training data. == Application in Action Recognition == Recent video segmentation algorithms often exploits both spatial and temporal attention mechanisms. Research in human action recognition has accelerated significantly since the introduction of powerful tools such as Convolutional Neural Networks (CNNs). However, effective methods for incorporation of temporal information into CNNs are still being actively explored. Motivated by the popular recurrent attention models in natural language processing, the Attention-aware Temporal Weighted CNN (ATW CNN) is proposed in videos, which embeds a visual attention model into a temporal weighted multi-stream CNN. This attention model is implemented as temporal weighting and it effectively boosts the recognition performance of video representations. Besides, each stream in the proposed ATW CNN framework is capable of end-to-end training, with both network parameters and temporal weights optimized by stochastic gradient descent (SGD) with back-propagation. Experimental results show that the ATW CNN attention mechanism contributes substantially to the performance gains with the more discriminative snippets by focusing on more relevant video segments. == Literature == Seibold VC, Balke J and Rolke B (2023): Temporal attention. Front. Cognit. 2:1168320. doi: 10.3389/fcogn.2023.1168320.
Hans Uszkoreit
Hans Uszkoreit is a German computational linguist. Hans Uszkoreit studied Linguistics and Computer Science at Technische Universität Berlin and the University of Texas at Austin. While he was studying in Austin, he also worked as a research associate in a large machine translation project at the Linguistics Research Center. After he received his Ph.D. in linguistics from the University of Texas, he worked as a computer scientist at the Artificial Intelligence Center and was affiliated with the Center for the Study of Language and Information at Stanford University. Nowadays, he is teaching as a professor of Computational Linguistics at Saarland University. Moreover, he serves as a Scientific Director at the German Research Center for Artificial Intelligence (DFKI) where he heads the DFKI Language Technology Lab. == Life and career == Hans Uszkoreit, a native of East Berlin, was actively involved in a group of young individuals who opposed the East Germany regime. His protesting against the 1968 invasion of Czechoslovakia led to his expulsion from high school and subsequent imprisonment for a period of fifteen months on charges of subversive agitation. Realizing that continuing his education in East Germany was not feasible, Uszkoreit made the decision to escape to West Berlin. There, he completed his high school education and pursued a degree in Linguistics and Computer Science at Technische Universität Berlin. During his time as a student, he worked part-time as an editor and writer for Zitty, a city magazine, which he co-founded. In 1977, Uszkoreit was granted a Fulbright Grant to further his studies at the University of Texas at Austin. During his time in Austin, he concurrently served as a research associate in a significant machine translation project. Subsequently, he received a second Fulbright grant, which enabled him to pursue a Ph.D. program in linguistics. In 1984, he successfully completed his doctoral studies, earning a Ph.D. in linguistics. Between 1982 and 1986, Uszkoreit held the position of a computer scientist at the Artificial Intelligence Center of SRI International in Menlo Park, California. In 1988, he created the Department of Computational Linguistics and Phonetics at Saarland University. In 1989 he was elected head of the Language Technology Lab at DFKI. In 2012, Uszkoreit's achievements in the domain of relation extraction led to his receipt of a Google Faculty Research Award, acknowledging the substantial progress made by Uszkoreit and his team in advancing the field. In 2013, Uszkoreit, in collaboration with Feiyu Xu and Roberto Navigli, was granted an additional Google Research Award, which provided support for a targeted project within Google's Language Understanding Program, focusing on the augmentation of language comprehension and analysis. == Personal life == He is father of a son Jakob Uszkoreit, machine learning researcher scientist, an author of the landmark paper "Attention Is All You Need", and daughter Lena Uszkoreit. == Awards == 2002 Elected Member of the European Academy of Sciences 2012 Google Faculty Research Award 2013 Google Focused Research Award